Isabela is the captain of the pirate ship Siren's Call in Dragon Age: Origins and Dragon Age II. Something of a firecracker, and unapologetically independent, she is also a dueling specialist.

Either male or female characters have the option to enter a romantic relationship with Isabela. She also knows Zevran from before, and it's clear that they have had a sexual relationship in the past. In fact, players have the option to join her and Zevran in bi group sex more than once in the second Dragon Age entry.